What is Tamoxifen?
Tamoxifen is a Selective Estrogen Receptor Modulator (SERM) used to prevent breast cancer in women and men, among other uses. Do not confuse it with Selective Androgen Receptor Modulators (SARMs) as these are two completely different types of medications. Tamoxifen is most popular as the brand name Nolvadex although it is available as other trade names. This is a medication taken daily by mouth. Dosage and cycle length depends on the goals, who exactly takes it, and individual response to the compound. It is used in medical settings mainly to treat breast cancer, but it is also used by people who use performance enhancing drugs (PEDs) to prevent/treat gynecomastia and/or to boost natural testosterone production after it gets inhibited by the use of PEDs. Such as anabolic steroids and/or SARMs. Tamoxifen is effective as a gynecomastia treatment/prevention and as a PCT medication.
Is Tamoxifen chemotherapy?
No, Tamoxifen (Nolvadex) is not chemotherapy. However, some may think this way because it is a type of medication used to treat breast cancer. Chemotherapy medications are those that kill rapidly dividing cells. Tamoxifen, on the other hand, is a selective estrogen receptor modulator (SERM) that will bind to estrogen receptors and block their activity, especially in breast tissues. Considering there are breast cancers that require estrogen hormone to form and grow, tamoxifen is effective for treating breast cancer because it blocks estrogen from reaching the breast tissues, therefore stopping the growth of breast cancer. But it doesn’t work by killing rapidly dividing cells, it is not chemotherapy.
What are the worst side effects of tamoxifen?
The worst side effects related to the use of tamoxifen are endometrial cancer, blood clots, stroke, and eye problems. The good news is that these side effects usually appear after using this steroid for many years and in larger doses only. Even this way, not everyone develops such side effects. It is rare to experience such issues. It is almost impossible to use it when using it for treating/preventing gynecomastia or for PCT medications. SARM users require Nolvadex mostly as a Post Cycle Therapy (PCT) medication. That’s because SARMs do not aromatize into estrogen. They do not increase estrogen levels like anabolic steroids do, so they do not cause gynecomastia (gyno). Therefore, the only reason why a SARM user may need Nolvadex is for PCT. You do not need large doses for PCT and you use it for short periods. Therefore, side effects are very unlikely to occur.
What is tamoxifen used for?
Tamoxifen (Nolvadex) is used for treating hormone receptor positive breast cancer in women and men. However, it may have other uses as well such as dysmenorrhea, infertility treatment, gynecomastia, and peripheral precocious puberty due to McCune-Albright syndrome in both girls and boys. However, Tamoxifen is also used for Post Cycle Therapy (PCT) purposes. When using Anabolic and Androgenic Steroids (AAS) and/or Selective Androgen Receptor Modulators (SARMs), they suppress natural testosterone production. Nolvadex binds to estrogen receptors in the pituitary gland, and this makes the gland release more Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). These hormones are necessary to produce natural testosterone. This way, Nolva is effective as a PCT medication because it helps boost natural testosterone production after it gets suppressed by the cycle of PEDs.
Does tamoxifen cause weight gain?
Yes, tamoxifen causes weight gain. This is a common side effect of taking tamoxifen. It could do so because it affects your estrogen and testosterone hormones. This could affect your appetite and/or water retention. Therefore, this could cause weight gain.
How does tamoxifen work?
Tamoxifen works by binding to estrogen receptors in breast cancer cells and blocking their activity. It prevents estrogen from binding to those receptors and, therefore stops the cancer cells from receiving the hormone that they need to grow. It works as an antagonist (blocks the activity) of estrogen receptors in particular parts of the body (in the breast tissues, which is why it is effective for treating gynecomastia and breast cancer) and in the pituitary gland (making it release more LH and FSH, leading to more testosterone). But it also works as an agonist (activates the activity) of estrogen receptors in other parts of the body, such as in bones, preventing/treating osteoporosis and bone fractures.
Does tamoxifen cause hair loss?
While it is possible for tamoxifen to cause hair thinning, it is usually temporary (hair grows back after stopping it) and very rare. It is also something that you are highly unlikely to experience when using it as a PCT for SARMs.
Is tamoxifen an aromatase inhibitor?
No, tamoxifen is not an aromatase inhibitor. It does not bind to aromatase enzymes and blocks them, therefore reducing total estrogen levels in the body. Instead, it is a selective estrogen receptor modulator (SERM), which means that it works by binding to androgen receptors in the body, working as an agonist (activating their activity) in some parts of the body, and an antagonist in others parts of the body (blocking estrogen receptors activity).
What is the lowest effective dose of tamoxifen?
The lowest effective dose of tamoxifen is 2.5mg per day. However, it may not be as effective as 10-20 mg/day when using it for boosting natural testosterone production after a SARM cycle for Post Cycle Therapy (PCT) purposes. Usually, the dosage of tamoxifen for PCT purposes is 40 mg per day for the first 2 weeks and then 20 mg a day for the last 2 weeks (4 weeks total PCT length). Although you may lower the dosage if you need to.
Does tamoxifen cause bone loss?
Tamoxifen works as an agonist of estrogen receptors in bones (activates their activity). This may cause postmenopausal women to improve their bone density. However, it may cause premenopausal women to experience bone loss (bone thinning) as it may deplete estrogen systemically, harming bone health. It is unclear how it may affect bone density in men, but it is unlikely to cause anything drastic due to the short length of use.
Where to buy tamoxifen?
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